Title of article
Pyrimidinone antibiotics—heterocyclic analogues with improved antibacterial spectrum
Author/Authors
Michael Brands، نويسنده , , Yolanda Cancho Grande، نويسنده , , Rainer Endermann، نويسنده , , Reinhold Gahlmann، نويسنده , , Jochen Krüger، نويسنده , , Siegfried Raddatz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
2641
To page
2645
Abstract
We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B containing heterocycles either in the β-amino acid side chain or as mimics of the urea function. In the course of this program, we identified novel analogues that display activity towards a broader panel of Gram-positive bacteriae.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793417
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