Title of article
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines
Author/Authors
John F. Beattie، نويسنده , , Gloria A. Breault، نويسنده , , Rebecca P. A. Ellston، نويسنده , , Stephen Green، نويسنده , , Philip J. Jewsbury، نويسنده , , Catherine J. Midgley، نويسنده , , Russell T. Naven، نويسنده , , Claire A. Minshull، نويسنده , , Richard A. Pauptit، نويسنده , , Julie A. Tucker and Ric، نويسنده , , J. Elizabeth Pease، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
2955
To page
2960
Abstract
Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793486
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