Title of article
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I
Author/Authors
David M. Vigushin، نويسنده , , Greg Brooke، نويسنده , , David Willows، نويسنده , , R.Charles Coombes، نويسنده , , Christopher J. Moody، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3661
To page
3663
Abstract
Some pyrazino[1,2-a]indole-1,4-diones, structurally simplified analogues of the natural mycotoxin gliotoxin, have been synthesised and investigated as inhibitors of prenyltransferases; one compound, 3-acetylthio-9-methoxy-2-methyl-2,3-dihydropyrazino[1,2-a]indole-1,4-dione 10 shows slightly greater selectivity (8-fold) for geranylgeranyltransferase type I (GGTase I) than gliotoxin tself.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793630
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