Title of article
Precursor-Directed polyketide biosynthesis in Escherichia coli
Author/Authors
Kenji Kinoshita، نويسنده , , Blaine A Pfeifer، نويسنده , , Chaitan Khosla and Robert M. Stroud، نويسنده , , David E. Cane، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3701
To page
3704
Abstract
Precursor-directed polyketide biosynthesis was demonstrated in the heterologous host Escherichia coli. Several diketide and triketide substrates were fed to a recombinant E. coli strain containing a variant form of deoxyerythronolide B synthase (DEBS) from which the first elongation module was deleted resulting in successful macrolactone formation from the diketide, but not the triketide, substrates.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793639
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