Title of article
A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-Benzothiazepines
Author/Authors
Michael B. Tollefson، نويسنده , , Stephen A. Kolodziej، نويسنده , , Theresa R. Fletcher، نويسنده , , William F. Vernier، نويسنده , , Judith A. Beaudry، نويسنده , , Bradley T. Keller، نويسنده , , David B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3727
To page
3730
Abstract
A series of 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol 1,1-dioxides were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT) for the potential treatment for hyperlipidemia. Several 1,2-benzothiazepines exhibited low nanomolar in vitro activity. The synthesis and initial in vitro potency data is presented for this novel class of compounds.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793645
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