Title of article
Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity
Author/Authors
Diane H. Boschelli، نويسنده , , Fei Ye، نويسنده , , Biqi Wu، نويسنده , , Yanong D. Wang، نويسنده , , Ana Carolina Barrios Sosa، نويسنده , , Deanna Yaczko، نويسنده , , Dennis Powell، نويسنده , , Jennifer M. Golas، نويسنده , , Judy Lucas، نويسنده , , Frank Boschelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3797
To page
3800
Abstract
Several 7-alkoxy-4-anilino-3-quinolinecarbonitriles were synthesized and evaluated for Src kinase inhibitory activity. Optimal inhibition of both Src enzymatic and cellular activity was seen with analogues having a 2,4-dichloro-5-methoxyaniline group at C-4. Compound 18, which has a 1-methylpiperidinemethoxy group at C-7, showed in vivo activity in a xenograft model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793660
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