Title of article
Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism
Author/Authors
Min Chu، نويسنده , , Ronald Mierzwa، نويسنده , , Ling Xu، نويسنده , , Shu-Wei Yang، نويسنده , , Ling He، نويسنده , , Mahesh Patel، نويسنده , , Jill Stafford، نويسنده , , David Macinga، نويسنده , , Todd Black، نويسنده , , Tze-Ming Chan، نويسنده , , Vincent Gullo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3827
To page
3829
Abstract
A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound 1 exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC50 value of 4.19 μM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793667
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