Title of article
Synthesis and biological activities of novel 4″-alkylidene avermectin derivatives
Author/Authors
Kenichiro Nagai، نويسنده , , Toshiaki Sunazuka، نويسنده , , Kazuro Shiomi، نويسنده , , Achim Harder، نويسنده , , Andreas Turberg، نويسنده , , Satoshi mura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3943
To page
3946
Abstract
Horner–Emmons reaction of 4″-dehydro-5-O-TBDMS-avermectin B1a with a variety of phosphorus ylides using LHMDS gave novel 4″-alkylidene avermectin derivatives in high yields. Further modifications led to derivatives bearing diverse functional groups. The new avermectin derivatives showed potent growth inhibitory activity against Artemia salina and Caenorhabditis elegans.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793691
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