Title of article
Dehydroabietic acid derivatives as a novel scaffold for large-Conductance calcium-Activated K+ channel openers
Author/Authors
Tomohiko Ohwada، نويسنده , , Taro Nonomura، نويسنده , , Keisuke Maki، نويسنده , , Kazuho Sakamoto، نويسنده , , Susumu Ohya، نويسنده , , Katsuhiko Muraki، نويسنده , , Yuji Imaizumi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3971
To page
3974
Abstract
We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K+ channels (BK channels). Structure–activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793698
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