Title of article
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents
Author/Authors
Maria Zappalà، نويسنده , , Silvana Grasso، نويسنده , , Nicola Micale، نويسنده , , Giuseppe Zuccalà، نويسنده , , Frank S. Menniti، نويسنده , , Guido Ferreri، نويسنده , , Giovambattista De Sarro، نويسنده , , Carlo De Micheli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4427
To page
4430
Abstract
A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a–f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793794
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