Title of article
Synthesis and Anti-HIV properties of new water-soluble bis-functionalized[60]fullerene derivatives
Author/Authors
Susanna Bosi، نويسنده , , Tatiana Da Ros، نويسنده , , Giampiero Spalluto، نويسنده , , Jan Balzarini، نويسنده , , Maurizio Prato، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4437
To page
4440
Abstract
A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2 strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2 isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793796
Link To Document