Title of article
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity
Author/Authors
Christopher McGuigan، نويسنده , , Andrea Brancale، نويسنده , , Graciela Andrei، نويسنده , , Robert Snoeck، نويسنده , , Erik De Clercq، نويسنده , , Jan Balzarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
4511
To page
4513
Abstract
Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793813
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