• Title of article

    New orally active PDE4 inhibitors with therapeutic potential

  • Author/Authors

    Hiroshi Ochiai، نويسنده , , Akiharu Ishida، نويسنده , , Tazumi Ohtani، نويسنده , , Kensuke Kusumi، نويسنده , , Katuya Kishikawa، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    4
  • From page
    29
  • To page
    32
  • Abstract
    Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure–activity relationships are discussed.
  • Keywords
    PDE4 , Pyrazolopyrioline , inhibitor , Orally active.* Corresponding author. Tel.:+81-75-961-1151 , fax:+81-75-962-9314 , e-mail: hi.nakai@ono.co.jp
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    793918

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793918