Title of article
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
Author/Authors
Dawei Ma، نويسنده , , Wengen Wu، نويسنده , , Guoxin Yang، نويسنده , , Jingya Li، نويسنده , , Jia Li، نويسنده , , Qizhuang Ye، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
47
To page
50
Abstract
The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793922
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