Title of article
Synthesis and SAR of potent EGFR/erbB2 dual inhibitors
Author/Authors
Yue Mei Zhang، نويسنده , , Stuart Cockerill، نويسنده , , Stephen B. Guntrip، نويسنده , , David Rusnak، نويسنده , , Kathryn Smith، نويسنده , , Dana Vanderwall، نويسنده , , Edgar Wood، نويسنده , , Karen Lackey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
111
To page
114
Abstract
A series of 6-alkoxy-4-anilinoquinazoline compounds was prepared and evaluated for in vitro inhibition of the erbB2 and EGFR kinase activity. The IC50 values of the best compounds were below 0.10 uM. Further, several of these compounds inhibit the growth of erbB2 and EGFR over-expressing tumor cell lines at concentrations below 1 uM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793936
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