Title of article
Inactivation of γ-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism
Author/Authors
Mengmeng Fu، نويسنده , , Richard B. Silverman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
203
To page
206
Abstract
Inactivation of pyridoxal 5′-phosphate (PLP)-dependent γ-aminobutryic acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (SADFA) gives pyridoxamine 5′-phosphate, not the expected SADFA-PLP aromatization product. Inactivation appears to proceed by a Michael addition/hydrolysis mechanism instead.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793955
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