Title of article
Highly potent PDE4 inhibitors with therapeutic potential
Author/Authors
Hiroshi Ochiai، نويسنده , , Tazumi Ohtani، نويسنده , , Akiharu Ishida، نويسنده , , Kensuke Kusumi، نويسنده , , Masashi Kato، نويسنده , , Hiroshi Kohno، نويسنده , , Katuya Kishikawa، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
207
To page
210
Abstract
Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793956
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