Title of article
Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
Author/Authors
Haiyin He، نويسنده , , Bo Shen، نويسنده , , Peter J. Petersen، نويسنده , , William J. Weiss، نويسنده , , Hui Y. Yang، نويسنده , , Ting-Zhong Wang، نويسنده , , Russell G. Dushin، نويسنده , , Frank E. Koehn، نويسنده , , Guy T. Carter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
279
To page
282
Abstract
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793970
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