Title of article
A novel series of potent and selective IKK2 inhibitors
Author/Authors
Alistair H. Bingham، نويسنده , , Richard J. Davenport، نويسنده , , Lewis Gowers، نويسنده , , Roland L. Knight، نويسنده , , Christopher Lowe، نويسنده , , David A. Owen، نويسنده , , David M. Parry، نويسنده , , Will R. Pitt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
409
To page
412
Abstract
A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.
Keywords
Potent , IKK2 , Selective , Inhibitors.* Corresponding author. Tel.: +44-1223-896491 , fax: +44-1223-
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793997
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