Title of article
3-(4-Aminobutyn-1-yl)pyridines: binding at α4β2 nicotinic cholinergic receptors
Author/Authors
Deniz Dogruer، نويسنده , , Mase Lee، نويسنده , , Malgorzata Dukat، نويسنده , , M. Imad Damaj، نويسنده , , Billy R. Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
523
To page
526
Abstract
The binding of a series pyridylbutynylamines 6 was examined at α4β2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794022
Link To Document