Title of article
Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase
Author/Authors
Lawrence G. Hamann، نويسنده , , Charles Z. Ding، نويسنده , , Arthur V. Miller، نويسنده , , Cort S. Madsen، نويسنده , , Paulina Wang، نويسنده , , Philip D. Stein، نويسنده , , Andrew T. Pudzianowski، نويسنده , , David W. Green، نويسنده , , Hossain Monshizadegan، نويسنده , , Karnail S. Atwal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1031
To page
1034
Abstract
A series of benzodiazepine-based inhibitors of mitochondrial F1F0 ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase versus ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease.
Keywords
Mitochondrial ATP hydrolase , ischemia , Heart disease.* Corresponding author. Tel.: +1-609-818-5526 , fax: +1-609-818-
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794125
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