Title of article
A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives
Author/Authors
Hitoshi Kurata، نويسنده , , Sayaka Suzuki، نويسنده , , Yasuo Ohhata، نويسنده , , Takuya Ikeda، نويسنده , , Toru Hasegawa، نويسنده , , Ken Kitayama، نويسنده , , Toshimori Inaba، نويسنده , , Keita Kono، نويسنده , , Takafumi Kohama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1183
To page
1186
Abstract
A series of 4-oxo-1-phenyl-1,4-dihydroquinolines possessing a linker and an ammonio moiety were synthesized and found to inhibit the apical sodium-dependent bile acid transporter (ASBT). The potency of ASBT inhibition varied with the position and length of the linking tether. Compound 21e effectively lowered the total serum cholesterol levels in hamsters.
Keywords
Apical sodium-dependent bile acid transporter (ASBT) , Ileal bile acid transporter (IBAT).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794156
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