Title of article
KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine
Author/Authors
Tooru Kimura، نويسنده , , Daisuke Shuto، نويسنده , , Soko Kasai، نويسنده , , Ping Liu، نويسنده , , Koushi Hidaka، نويسنده , , Takashi Hamada، نويسنده , , Yoshio Hayashi، نويسنده , , Chinatsu Hattori، نويسنده , , Masashi Asai، نويسنده , , Shinobu Kitazume، نويسنده , , Takaomi C. Saido، نويسنده , , Shoichi Ishiura، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
1527
To page
1531
Abstract
Recently, we reported a novel substrate-based octapeptide BACE1 inhibitor KMI-008 containing hydroxymethylcarbonyl (HMC) isostere as a transition-state mimic. Using KMI-008 as a lead compound, a small-sized and highly potent BACE1 inhibitor KMI-370 (IC50=3.4 nM) was designed and synthesized.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794227
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