Title of article
Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480
Author/Authors
Gianluca Sbardella، نويسنده , , Antonello Mai، نويسنده , , Marino Artico، نويسنده , , Roberta Loddo، نويسنده , , Maria Grazia Setzu، نويسنده , , Paolo La Colla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
1537
To page
1541
Abstract
Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).
Keywords
fax: +39-0644-62731 , oxazolidinones , Antitubercular drugs.* Corresponding author. Tel.: +39-0644-62731 , MAC , tuberculosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794229
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