Title of article
Synthesis and biological activity of selective azasugar-based TACE inhibitors
Author/Authors
Takahiro Tsukida، نويسنده , , Hideki Moriyama، نويسنده , , Yoshimasa Inoue، نويسنده , , Hirosato Kondo، نويسنده , , Kohichiro Yoshino، نويسنده , , Shin-ichiro Nishimura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1569
To page
1572
Abstract
A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794236
Link To Document