Title of article
Epibatidine structure–activity relationships
Author/Authors
F. Ivy Carroll، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
1889
To page
1896
Abstract
Epibatidine is a potent but nonselective nAChR agonist. Its biological effects appear to be mediated largely by α4β2 nAChRs. Surprisingly, only a limited number of epibatidine analogues have been synthesized and evaluated in in vitro assays. Even fewer analogues have received in vivo pharmacological evaluation. In this paper, SAR studies directed toward epibatidine analogues will be reviewed.
Keywords
e-mail: fic@rti.org , Nicotine , Epibatidine , SAR , Nicotinic receptors , nAChRs.* Tel.: +1-919-541-6679 , fax: +1-919-541-8868
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794304
Link To Document