Title of article
Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists
Author/Authors
Irini Akritopoulou-Zanze، نويسنده , , Jyoti R Patel، نويسنده , , Kresna Hartandi، نويسنده , , Jehrod Brenneman، نويسنده , , Martin Winn، نويسنده , , John K Pratt، نويسنده , , Marlene Grynfarb، نويسنده , , Annika Goos-Nisson، نويسنده , , Thomas W von Geldern، نويسنده , , Philip R Kym، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2079
To page
2082
Abstract
We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.
Keywords
Glucocorticoid receptor (GR) antagonists , chromenes , Nonsteroidal.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794341
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