Title of article
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase
Author/Authors
Hea Ok Kim، نويسنده , , Su Jeong Yoo، نويسنده , , Hee-Sung Ahn، نويسنده , , Won-Jun Choi، نويسنده , , Hyung Ryong Moon، نويسنده , , Kang Man Lee، نويسنده , , Moon Woo Chun and، نويسنده , , Lak Shin Jeong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
2091
To page
2093
Abstract
Fluoro-DHCeA (4) was efficiently synthesized from d-cyclopentenone derivative 5 using electrophilic fluorination as a key step. Fluoro-DHCeA (4) was found to be as potent as DHCeA (3), but exhibited irreversible inhibition of enzyme unlike DHCeA (3) showing reversible inhibition. From this study, 4′-hydroxymethyl groups of neplanocin A and fluoro-neplanocin A played an important role in binding to the active site of the enzyme.
Keywords
S-Adenosylhomocysteine hydrolase , Electrophilicfluorination , Carbocyclic nucleosides. , antiviral
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794344
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