Title of article
Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase
Author/Authors
Xiaohui Liu، نويسنده , , Glenn D. Prestwich، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2137
To page
2140
Abstract
Didehydrofarnesyl diphosphate (ΔΔFPP), a fluorescent pentaene analogue of farnesyl diphosphate (FPP), was synthesized using stereoselective Wittig reactions. Although ΔΔFPP was not an alternative substrate for yeast protein farnesyltransferase (FTase), the fluorescent analogue was a potent competitive inhibitor with a Ki value of 8.8 μM (Km (FPP)=27 μM).
Keywords
Pentaene , FTase , GGTase-I , Inhibitor , Protein prenylation. , Farnesol , Geranylgeran iol , Stereosel ective Wittig
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794354
Link To Document