Title of article
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins
Author/Authors
Massimo Curini، نويسنده , , Francesco Epifano، نويسنده , , Federica Maltese، نويسنده , , Maria C Marcotullio، نويسنده , , Aurelia Tubaro، نويسنده , , Gianmario Altinier، نويسنده , , Sylvia Prieto Gonzales، نويسنده , , Juan C Rodriguez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
2241
To page
2243
Abstract
Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1 μmol/cm2) provoked 50% oedema reduction, similarly to 0.25 μmol/cm2 of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.
Keywords
Collinin , Anti-inflammatoryactivity. , Geranyloxycoumarins , Auraptene
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794375
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