Title of article
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity
Author/Authors
Christophe Bénard، نويسنده , , Fatima Zouhiri، نويسنده , , Marie Normand-Bayle، نويسنده , , Michèle Danet، نويسنده , , Didier Desmaële، نويسنده , , Hervé Leh، نويسنده , , Jean-François Mouscadet، نويسنده , , Gladys Mbemba، نويسنده , , Claire-Marie Thomas، نويسنده , , Sabine Bonnenfant، نويسنده , , Marc Le Bret، نويسنده , , Jean dʹAngelo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2473
To page
2476
Abstract
A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-1-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments.
Keywords
antivirals , Enzyme inhibitors , Quinolines , Amides , Ureas.* Corresponding authors. Tel.: +33-(0)146835699 , fax: +33-(0)14683-5752 , e-mail: jean.dangelo@cep.u-psud.fr
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794421
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