Title of article
Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters
Author/Authors
Farhanullah، نويسنده , , Diptesh Sil، نويسنده , , Brajendra K. Tripathi، نويسنده , , Arvind K. Srivastava، نويسنده , , Vishnu Ji Ram، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2571
To page
2574
Abstract
A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a–j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g–j) displayed significant inhibitory activity of the enzyme.
Keywords
Hyperglycemic. , Thiouriedoalkanoic acid , Glucose-6-phosphatase , Hyperinsulinemic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794440
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