Title of article
Design and synthesis of benzofused heterocyclic RXR modulators
Author/Authors
D.L. Gernert، نويسنده , , D.A. Neel، نويسنده , , M.F. Boehm، نويسنده , , M.D. Leibowitz، نويسنده , , D.A. Mais، نويسنده , , P.Y. Michellys، نويسنده , , D. Rungta، نويسنده , , A. Reifel-Miller، نويسنده , , T.A. Grese، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2759
To page
2763
Abstract
Benzofused heterocyclic analogs of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRα and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the choice of heterocycle as well as the sidechain employed.
Keywords
RXR , Heterocycles , Trienoic acid.* Corresponding authors. Tel.: +1-317-433-0430 , fax: +1-317-276-24-41 , e-mail addresses: dgernert@lilly.com , neelda@lilly.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794478
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