Title of article
Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity
Author/Authors
Akihiko Tanitame، نويسنده , , Yoshihiro Oyamada، نويسنده , , Keiko Ofuji، نويسنده , , Kenji Suzuki، نويسنده , , Hideaki Ito، نويسنده , , Motoji Kawasaki، نويسنده , , Masaaki Wachi، نويسنده , , Jun-ichi Yamagishi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2863
To page
2866
Abstract
In this study, we designed and synthesized novel 5-vinylpyrazole analogues by decreasing the lipophilicity of the parent compounds 1a,b; 3-[(3-methoxycarbonyl)cyclohexylaminomethyl]indazoles while keeping the van der Waals interaction with the lipophilic area of DNA gyrase B. The selected compound 8bb exhibited good antibacterial activity against staphylococci and enterococci, including multi-drug resistant strains.
Keywords
DNA gyrase inhibitor , 5-Vinylpyrazole analogues , Multidrugresistant strains.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794498
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