Title of article
Plasmepsin II inhibition and antiplasmodial activity of Primaquine–Statine `double-drugsʹ
Author/Authors
Sergio Romeo، نويسنده , , Mario DellʹAgli، نويسنده , , Silvia Parapini، نويسنده , , Luca Rizzi، نويسنده , , Germana Galli، نويسنده , , Monica Mondani، نويسنده , , Anna Sparatore، نويسنده , , Donatella Taramelli، نويسنده , , Enrica Bosisio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2931
To page
2934
Abstract
Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the `double-drugʹ approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 μM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
Keywords
In vitro inhibition. , P. falciparum , Plasmepsin II , Statine , Primaquine , Doubledrug , Chimera drug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794512
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