Title of article
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives
Author/Authors
Noriyasu Haginoya، نويسنده , , Syozo Kobayashi، نويسنده , , Satoshi Komoriya، نويسنده , , Yumiko Hirokawa، نويسنده , , Taketoshi Furugori، نويسنده , , Takayasu Nagahara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2935
To page
2939
Abstract
In our investigation of factor Xa inhibitors, a series of 1-(6-chloronaphthalen-2-yl)sulfonyl-4-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carbonyl)piperazines 3a–i were synthesized. In vitro inhibitory activities of the compounds against factor Xa and coagulation are summarized. Among the compounds, 3c and 3d, possessing a carbamoyl or N-methylcarbamoyl moiety, showed potent inhibitory activities when administered orally to rats.
Keywords
4-c]pyridine. , 6 , 4 , Factor Xa inhibitor , 5
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794513
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