Title of article
The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase
Author/Authors
Mark T. Bilodeau، نويسنده , , Leonard D. Rodman، نويسنده , , Georgia B. McGaughey، نويسنده , , Kathleen E. Coll، نويسنده , , Timothy J. Koester، نويسنده , , William F. Hoffman، نويسنده , , Randall W. Hungate، نويسنده , , Richard L. Kendall، نويسنده , , Rosemary C. McFall، نويسنده , , Keith W. Rickert، نويسنده , , Ruth Z. Rutledge، نويسنده , , Kenneth A. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2941
To page
2945
Abstract
An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. This new class has been found to be potent, selective, and of low molecular weight. Molecular modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme.
Keywords
KDR kinase , VEGF.* Corresponding author. Tel.: +1-215-652-5304 , fax: +1-215-652-7310 , e-mail: mark_bilodeau@merck.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794514
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