Title of article
Evaluation of series of isobenzofuranone dimers as PKCα ligands: implication for the distance between the two ligand binding sites
Author/Authors
Yoshiyasu Baba، نويسنده , , Satoshi Mayumi، نويسنده , , Go Hirai، نويسنده , , Hidekazu Kawasaki، نويسنده , , Yosuke Ogoshi، نويسنده , , Takeshi Yanagisawa، نويسنده , , Yuichi Hashimoto، نويسنده , , Mikiko Sodeoka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2969
To page
2972
Abstract
Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuranone dimers. Peak binding activities were observed for the C3-acyl chain dimers having a C10–C12 linker and for the C7 dimers having a C14–C16.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794520
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