Title of article
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones
Author/Authors
Michele A. Weidner-Wells، نويسنده , , Harvey M. Werblood، نويسنده , , Raul Goldschmidt، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Barbara D. Foleno، نويسنده , , Jamese J. Hilliard، نويسنده , , John Melton، نويسنده , , Ellyn Wira، نويسنده , , Mark J. Macielag، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3069
To page
3072
Abstract
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
Keywords
Antibacterial , oxazolidinone , fax: +1-908-203-8109 , e-mail: mwells@prdus.jnj.com , Resistant bacteria.* Corresponding author. Tel.: +1-908-704-5933
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794536
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