Title of article
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs
Author/Authors
Ben B. Wang، نويسنده , , Nima Maghami، نويسنده , , Vanessa L. Goodlin، نويسنده , , Paul J. Smith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
3221
To page
3226
Abstract
Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition.
Keywords
Topoisomerase II , UK-1 , e-mail: pjsmith@umbc.edu , fax: +1-410-455-2608 , Benzoxazole.* Corresponding author. Tel.: +1-410-455-2519
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794569
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