Title of article
Anti-AIDS agents. Part 58: Synthesis and anti-HIV activity of 1-thia-di-O-(−)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues
Author/Authors
Peng-Xia Liu، نويسنده , , Zhi-Jian Yin، نويسنده , , Ying Chen، نويسنده , , Qian Zhang، نويسنده , , Beina Zhang، نويسنده , , Yi Xia، نويسنده , , Zhengyu Yang، نويسنده , , Nicole Kilgore، نويسنده , , Carl Wild، نويسنده , , Susan L. Morris-Natschke، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
3341
To page
3343
Abstract
Two 1-thia-DCK analogues (9a and 9b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 9a showed excellent anti-HIV activity with an EC50 value of 0.00012 μM and therapeutic index of 1,408,000. Compound 9b was less active with EC50 and TI values of 3.11 μM and 62.3, respectively. The bioassay results indicated that thia-DCK analogues merit attention as potential HIV-1 inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794593
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