Title of article
Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides
Author/Authors
Nobutoshi Murakami، نويسنده , , Motoyuki Kawanishi، نويسنده , , Sawako Itagaki، نويسنده , , Toshihiro Horii، نويسنده , , Motomasa Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3513
To page
3516
Abstract
The reactants of an anti-malarial peroxide having a 6-carbomethoxymethyl-3-methoxy-1,2-dioxane moiety treated with FeSO4 were analyzed. For mechanistic study of the anti-malarial peroxide, two biotinylated probes to elucidate the target molecules were designed and synthesized. The two synthesized probes showed potent anti-malarial activity, and one of them was proved to form an irreversible binding with protein in a model experiment.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794625
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