Title of article
Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives
Author/Authors
B. Narasimhulu Naidu، نويسنده , , Margaret E. Sorenson، نويسنده , , Thomas Hudyma، نويسنده , , Xiaofan Zheng، نويسنده , , Yunhui Zhang، نويسنده , , Joanne J. Bronson، نويسنده , , Michael J. Pucci، نويسنده , , Junius M Clark، نويسنده , , Yasutsugu Ueda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3743
To page
3746
Abstract
The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1–12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7–9 also exhibited potent in vivo activity.
Keywords
Antibacterial activity , Nocathiacin , Natural product.* Corresponding author. Tel.: +1-203-677-6574 , fax: +1-203-677-7702 , e-mail: narasimhulu.naidu@bms.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794672
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