Title of article
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins
Author/Authors
Zhen-Qiang Tan، نويسنده , , Elizabeth T. Birzin، نويسنده , , Wanda Chan، نويسنده , , Yi Tien Yang، نويسنده , , Lee-Yuh Pai، نويسنده , , Edward C Hayes، نويسنده , , Carolyn A DaSilva، نويسنده , , Frank DiNinno، نويسنده , , Susan P Rohrer، نويسنده , , James M. Schaeffer، نويسنده , , Milton L. Hammond، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
3753
To page
3755
Abstract
Dihydrobenzodithiin compounds (1–6) were prepared to explore the expansion of the dihydrobenzoxathiin lead compounds I–III as SERAMs (Selective Estrogen Receptor Alpha Modulators). The dihydrobenzodithiin compounds generally maintained a high degree of selectivity for ERα over ERβ, however, they lacked the in vivo antagonism/agonism activity exhibited by the lead class in an immature rat uterine growth model.
Keywords
SERAM.* Corresponding author. Tel.: +1-732-594-1276 , fax: +1-732-594-9556 , e-mail: qiang_tan@merck.com , Estrogen receptor , SERM , Dihydrobenzodithiins
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794674
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