Title of article
Fluorinated quinoid inhibitor: possible `pureʹ arylator predicted by the simple theoretical calculation
Author/Authors
Seung Wook Ham، نويسنده , , Jong-In Choe، نويسنده , , Meifang Wang، نويسنده , , Vincent Peyregne، نويسنده , , Brian I Carr، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
4103
To page
4105
Abstract
We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
Keywords
Reduction potential.* Corresponding author. Tel.: +1-412-624-6684 , fax: +1-412-624-6666 , Cdc25 inhibitor , e-mail: carrbi@msx.upmc.edu , Quinones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794744
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