Title of article
Structure–activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa
Author/Authors
Hiroshi Ueno ، نويسنده , , Susumu Katoh، نويسنده , , Katsuyuki Yokota، نويسنده , , Jun-ichi Hoshi، نويسنده , , Mikio Hayashi، نويسنده , , Itsuo Uchida، نويسنده , , Kazuo Aisaka، نويسنده , , Yasunori Hase، نويسنده , , Hidetsura Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
4281
To page
4286
Abstract
A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized. Compounds with substituted aminocarbonylmethyl groups as the side chain showed potent FXa inhibitory activity. Compounds 1 and 2 exhibited most potent inhibitory activity and were effective as anticoagulants in a DIC model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794779
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