Title of article
Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase
Author/Authors
Deane M Nason، نويسنده , , Steven D Heck، نويسنده , , Mathew S Bodenstein، نويسنده , , John A. Lowe III، نويسنده , , Robert B Nelson، نويسنده , , Dane R Liston، نويسنده , , Charles E Nolan، نويسنده , , Lorraine F Lanyon، نويسنده , , Karen L. Ward، نويسنده , , Robert A. Volkmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4511
To page
4514
Abstract
The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1–8 are described. These compounds are potent inhibitors of the human nNOS isoform.
Keywords
nNOS inhibitors.* Corresponding author. Tel.: +1-860-441-4662 , fax: +1-860-686-1060 , e-mail: robert_a_volkmann@groton.pfizer.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794822
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