Title of article
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
Author/Authors
K Shankaran، نويسنده , , Karla L. Donnelly، نويسنده , , Shrenik K. Shah، نويسنده , , Ravindra N. Guthikonda، نويسنده , , Malcolm MacCoss، نويسنده , , John L. Humes، نويسنده , , Stephen G. Pacholok، نويسنده , , Stephan K. Grant، نويسنده , , T.M Kelly، نويسنده , , K.K Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
4539
To page
4544
Abstract
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
Keywords
Pyrrolidin-2-imine , NOS , 1 , 3-Thiazolidin-2-imine.q See Ref. 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794828
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