Title of article
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase
Author/Authors
Mark C. Noe، نويسنده , , Sheri L. Snow، نويسنده , , Lilli A. Wolf-Gouveia، نويسنده , , Peter G. Mitchell، نويسنده , , Lori Lopresti-Morrow، نويسنده , , Lisa M. Reeves، نويسنده , , Sue A. Yocum، نويسنده , , Jennifer L. Liras، نويسنده , , Marcie Vaughn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4727
To page
4730
Abstract
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure–activity relationships are reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794862
Link To Document