Title of article
2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents
Author/Authors
Pei-Wen Hsieh، نويسنده , , Fang-Rong Chang، نويسنده , , Cheng-Hsien Chang، نويسنده , , Pei-Wen Cheng، نويسنده , , Lien-Chai Chiang، نويسنده , , Fu-Long Zeng، نويسنده , , Kuei-Hsiang Lin، نويسنده , , Yang-Chang Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
4751
To page
4754
Abstract
A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.
Keywords
Anti-HCoVs , ICAM-1.* Corresponding author. Tel.: +886-73121101x2197 , e-mail: yachwu@kmu.edu.tw , fax: +886-73114773 , Benzoxazinones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794867
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